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Trans-piceid inhibits NLRP3. 19 / 19
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"Therefore, we propose that polydatin may down-regulate NLRP3 by promoting NLRP3 degradation.The suppression of NLRP3 expression by polydatin was diminished when BMDMs were treated with MG132 or chloroquine (CQ) (Fig. 2L)."
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"Furthermore, we observed that polydatin could inhibit the formation of the NLRP3 complex at 3 distinct stages, a capability not achievable with MCC950 (Fig. 2E to H)."
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"Polydatin inhibits the assembly of the NLRP3 inflammasome and promotes NLRP3 degradation."
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"In addition, the hyperosmolar stress induced NLRP3 inflammasome pathway and ROS production were inhibited by polydatin."
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"Collectively, polydatin significantly inhibits the activation of the NLRP3 inflammasome and specifically promotes NLRP3 degradation."
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"Polydatin downregulated NLRP3, ASC, caspase-1, IL-1β, TG, and TC in the livers of fructose-fed rats."
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"Polydatin prevented the activation of NLRP3 inflammatory vesicles, restricted the production of inflammatory cytokines, and promoted autophagy via the NLRP3/mTOR pathway in atherosclerotic lesions generated in mice based on feeding high fat (Zhang X, Wang Z, Li X, Chen J, Yu Z, Li X, Sun C, Hu L, Wu M, Liu L. Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome."
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"Having confirmed that polydatin triggers NLRP3 degradation, we investigated the potential of polydatin to directly bind NLRP3, thereby suppressing NLRP3 inflammasome activation."
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"Next, we separated the pellets obtained after digitonin permeabilization (maintaining the basic cellular structure) and treated them with polydatin to assess whether polydatin could attenuate the stability of NLRP3 in a cage structure (Fig. 5C)."
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"Therefore, we treated BMDMs with or without polydatin before LPS stimulation to determine whether polydatin could attenuate the stabilizing effect of HSP90α on NLRP3."
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"Our results showed that polydatin similarly reduced the stabilizing effect of HSP90α on NLRP3 in this system."
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"Polydatin repressed Mycoplasma pneumoniae -induced pulmonary damage in mice by suppressing the activation of the NLRP3 inflammasome and the NF-κB pathway [107] ."
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"In the calcium oxalate, crystal-induced renal injury model, polydatin inhibited the activation of the NLRP3 inflammasome by reducing ROS in the cytoplasm and mitochondria, effectively alleviating inflammatory damage and crystal deposition in the kidney [69] (Table 4)."
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"Moreover, this study showed that polydatin effectively inhibited the NLRP3 in macrophages, pro-caspase-1 cleavage, secretion of inflammatory cytokines, and pyroptosis, while promoting the protective l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our study elucidated that polydatin treatment could inhibit the activation of iNOS and NLRP3 inflammasome in microglia.In conclusion, our results demonstrate that polydatin improved SCI-induced motor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-kappaB Pathway."
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"In mice infected with Mycoplasma pneumomiae, polydatin treatment can suppress NF-kappaB and NLRP3 signaling pathway activation, thereby attenuating lung inflammation and fibrosis."
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"Polydatin, a glycoside of resveratrol, can reduce the activation of the NLRP3 inflammasome and then relieve microglial inflammation, which has a neuroprotective effect on SCI (112)."
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"In earlier reports, polydatin suppresses NLRP3 inflammasome activation and ameliorates potassium oxonate induced kidney inflammation in rats XREF_BIBR, and enhances PPAR-alpha and inhibits SCD-1 in animal models induced by streptozocin or a high-fat diet XREF_BIBR, XREF_BIBR."
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