IndraLab

Statements

EBF2 binds USP2. 5 / 5
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"Moreover, immunofluorescence staining confirmed the interaction of USP2 and EBF2 in primary brown adipocytes ( xref K)."
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"Inhibition of the USP2–EBF2 axis significantly reduced the half-life of EBF2 protein and suppressed adipocyte thermogenesis."
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"Mechanistically, we demonstrated that USP2 directly interacts with EBF2 and reduces K63-linked polyubiquitination of EBF2 at residue K321, subsequently enhancing the EBF2-mediated adaptive thermogenesis."
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"Overall, we revealed a USP2-EBF2 axis in BAT thermogenesis, expanding our understanding of how ubiquitination dynamics influence metabolic adaptations, and identified USP2 as a potential therapeutic target for metabolic diseases."
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"To further determine the interaction between USP2 and EBF2, we constructed Flag-USP2 and HA-EBF2 plasmids and transfected them individually or together into HEK293T cells."
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