IndraLab

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UCHL1 inhibits autophagy. 10 / 10
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"Mutated UCH-L1 also inhibits CMA autophagy by interacting with the lysosomal receptor for CMA LAMP-2A [ xref ]."
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"However, we speculate that the aminochrome induced modification of UCH-L1 also impairs CMA autophagy."
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"These data suggest that inhibition of UCH-L1 activity induces activation of the autophagy pathway in a-syn tg mice but not in non tg mice."
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"A mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1), which is associated with familial PD, was reported to inhibit CMA autophagy by interacting with the lysosomal receptor of CMA LAMP-2A [XREF_BIBR]."
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"In summary, our results indicate that down-regulation of UCHL1 mediated by cPKCgamma may negatively regulate autophagy through ERK-mTOR pathway, which alleviates ischaemic neuronal injury."
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"Inhibition of UCH-L1 causes the upregulation of autophagy, which is involved in the removal of alpha-syn aggregates."
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"Down-regulation of UCHL1 mediated by cPKCgamma decreased OGD induced autophagy through ERK-mTOR pathway."
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"Interestingly, further experiments of the team showed that UCHL1 increased the protein content of p21 by inhibiting the autophagy lysosomal degradation of p21 rather than by inhibiting the ubiquitin-proteasome system (Ref."
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"Upregulation of UCHL1 can prevent cardiac remodeling and dysfunction after myocardial infarction by supporting autophagy flow and protein homeostasis (Wu et al., 2022)."
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"Unfolded UCHL1 also may inhibit autophagy under pathological conditions ( xref ; xref ) UCHL1 closely interacts with proteins of the neuronal cytoskeleton and may regulate axonal transport and maintain axonal integrity ( xref ; xref )."
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