IndraLab

Statements

USP47 activates CDH1. 6 / 6
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"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of E-cadherin and promoted EMT through deubiquitination of Snail."
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
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"KIFC3 and USP47 depletion enhances formation of a unique E-cadherin fragment."
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"USP47 regulates base excision repair, suppresses E-cadherin degradation, and facilitates NLRP3 inflammasome activation to release IL-1β and IL-18 [30–32]."
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"Therefore, the modulation of E-cadherin by USP47 may be related to the cell states."
34604226
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"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of CDH1 and promoted EMT through deubiquitination of SNAIL [ 21 ]."
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