IndraLab

Statements

USP47 activates CDH1. 5 / 5
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"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of E-cadherin and promoted EMT through deubiquitination of Snail."
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"Therefore, the modulation of E-cadherin by USP47 may be related to the cell states."
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"KIFC3 and USP47 depletion enhances formation of a unique E-cadherin fragment."
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"Depletion of KIFC3 or USP47 promotes cleavage of E-cadherin at a juxtamembrane region of the cytoplasmic domain, resulting in the production of a 90-kDa fragment and the internalization of E-cadherin."
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
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