IndraLab

Statements

Loratadine inhibits KCNH2. 4 / 12
2 4 2 | 4
reach
"However, loratadine (10 mumol/L) failed to inhibit HERG potassium channel and HERG K+."
11575008
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"Also, Katchman et al. [34] have shown that loratadine, the nonsedating 2nd generation antihistamine has blocked hERG current with IC 50 value of 4 μM, which is lower than that of chlorpheniramine (IC [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19497368
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"Finally, loratadine (10 microM) failed to inhibit HERG K+ channel currents expressed in Xenopus laevis oocytes."
9271355
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"According to the Canadian FDA report 64, loratadine does not significantly block hERG potassium channels under the same in vitro conditions for terfenadine which showed a strong hERG inhibition 64."
21902220