IndraLab

Statements

Loratadine inhibits KCNH2. 12 / 12
2 4 2 | 4
ctd
No evidence text available
29143966
drugbank
No evidence text available
10604956
drugbank
No evidence text available
9658196
reach
"However, loratadine (10 mumol/L) failed to inhibit HERG potassium channel and HERG K+."
11575008
tas
No evidence text available
15911273
tas
No evidence text available
21185626
reach
"Also, Katchman et al. [34] have shown that loratadine, the nonsedating 2nd generation antihistamine has blocked hERG current with IC 50 value of 4 μM, which is lower than that of chlorpheniramine (IC [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19497368
reach
"Finally, loratadine (10 microM) failed to inhibit HERG K+ channel currents expressed in Xenopus laevis oocytes."
9271355
ctd
No evidence text available
10604956
ctd
No evidence text available
9658196
ctd
No evidence text available
11705456
reach
"According to the Canadian FDA report 64, loratadine does not significantly block hERG potassium channels under the same in vitro conditions for terfenadine which showed a strong hERG inhibition 64."
21902220