IndraLab

Statements

Ethanol inhibits STAT1. 8 / 9
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"Alcohol also inhibited IFN induced up-regulation of Stat1 at these concentrations."
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"Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokineinduced STAT1 and STAT3 signaling in human monocytes."
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"Alcohol feeding remarkably increased the intensity of Casp8 but decreased the intensity of Stat1 (Figure 3d)."
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"As shown in Fig. 9, ethanol treatment decreased the pSTAT1 and STAT1 ratio in Hep G2 cells by 1.5-2-fold compared with untreated cells after 1 hr of IFNgamma exposure."
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"It appears that while STAT1 activity is abrogated by acute and chronic alcohol exposure, chronic alcohol enhances STAT3 and modulates alcohol induced steatosis and inflammation based on the cell-type in which it is expressed."
19398236
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"As we recently reported, ethanol feeding in the same mouse model decreased in vivo activation of interferon-sensitive genes (ISG), ISG15 and OASL, as the most downstream step of the JAK–STAT1 signalin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, ethanol exposure suppressed STAT1 attachment to DNA (XREF_FIG)."
19195028
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"Total STAT1 but not total STAT3 was also slightly decreased by alcohol (XREF_FIG)."
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