IndraLab

Statements


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"Alcohol also inhibited IFN induced up-regulation of Stat1 at these concentrations."

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"Total STAT1 but not total STAT3 was also slightly decreased by alcohol (XREF_FIG)."

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"It appears that while STAT1 activity is abrogated by acute and chronic alcohol exposure, chronic alcohol enhances STAT3 and modulates alcohol induced steatosis and inflammation based on the cell-type in which it is expressed."

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"As shown in Fig. 9, ethanol treatment decreased the pSTAT1 and STAT1 ratio in Hep G2 cells by 1.5-2-fold compared with untreated cells after 1 hr of IFNgamma exposure."

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"However, ethanol exposure suppressed STAT1 attachment to DNA (XREF_FIG)."