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Quetiapine inhibits KCNH2. 5 / 6
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"Recently, we found that quetiapine and norquetiapine blocked hERG current with a half-maximal inhibitory concentration of 8.3 and 10.8 μM, respectively ( Lee et al., 2018 ), and assumed that the inhib[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A previous report described how quetiapine blocked hERG current with an IC 50 of 5.8 μM ( Kongsamut et al., 2002 )."
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"In a study of antipsychotic drugs with hERG potassium channel blocking activity (including quetiapine), the effect of the drugs on the human heart (QT c change) correlated to total plasma concentratio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Quetiapine and norquetiapine inhibited the hERG tail currents at -50 mV in a concentration dependent manner with IC 50 values of 8.3 and 10.8 muM, respectively, which suggested equal potency."
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"Quetiapine reportedly blocks the hERG (human-Ether-a-go-go-Related Gene) potassium channel ( Kongsamut et al., 2002 ), which produces a rapid delayed rectifier (I Kr ) current and contributes to ventr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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