IndraLab

Statements

USP48 activates HMGA2. 7 / 7
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"Taken together, these human CRC data strongly support our experimental findings regarding USP48-mediated HMGA2 stabilization (Fig. 8M).4 Discussion."
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"Conversely, knockdown of USP48 enhances HMGA2 degradation."
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"We hypothesize that the SUMOylation of USP48 may interact with a non-classically conserved SIM motif (V-V-Q-K) in the HMGA2 protein, or induce conformational changes in USP48 to better accommodate the HMGA2 protein44."
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"We employed cycloheximide (CHX) to halt protein synthesis and demonstrated that USP48 modulated the stability of HMGA2."
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"Collectively, these findings suggest that USP48 enhances tumor metastasis largely by regulating HMGA2 in vitro and in vivo.3."
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"Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis."
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"Cotransfection of USP48 with HDAC4 or HDAC7 synergistically enhances HMGA2 stability, while cotransfection with SENP5 exhibits a weaker effect (Supporting Information Fig. S6A‒C)."
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