IndraLab

Statements

USP1 activates Neoplasm Metastasis. 9 / 9
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"USP1 dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells."
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"USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis."
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"Moreover, pharmacological inhibition USP1 by ML323 presented the similar effects on Hippo signaling pathway and suppressed OS growth and metastasis both in vitro and in vivo ."
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"Correction to: USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis."
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"Then, real-time cellular analysis (RTCA) showed that USP1 knockdown inhibited GC metastasis both in vitro and in vivo."
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"USP1 Promotes GC Metastasis via Stabilizing ID2."
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"Suppression of USP1, CDC20, and CASP1 inhibited tumor cell growth and metastasis in ERα KO (ER-/PR +) cell lines."
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"In conclusion, our study showed that USP1 promoted GC metastasis via stabilizing ID2 expression, which provides a potential biomarker and therapy target for GC."
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"Mechanically, we demonstrated that USP1 promoted GC metastasis via upregulating ID2 expression and further confirmed that USP1 stabilized ID2 expression through deubiquitinating ID2 in GC."
34873426