IndraLab

Statements

USP1 activates Neoplasm Metastasis. 23 / 23
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"USP1 interacts with KPNA2, and deubiquitination of KPNA2 is a key factor in USP1 promoting metastasis; therefore, USP1 inhibition can markedly reduce the migration of breast cancer cells [13]."
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"Mechanistically, USP1 promotes metastasis by stabilizing the inhibitor of DNA binding-2 protein [18]."
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"USP1 dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells."
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"These findings demonstrated that USP1 and Vimentin, the target genes of HuR, mediate circUSP1 promotive effects on the growth and metastasis of GC cells."
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"USP1 is upregulated in GC and promotes GC cell growth and metastasis."
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"In breast cancer, the upregulation of USP1 expression and deubiquitination of KPNA promotes cell proliferation, migration, and invasion in vitro and promotes lung metastasis of breast cancer cells [13]."
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"Taken together, these results indicated that USP1 promotes the growth and metastasis of GC cells."
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"Moreover, pharmacological inhibition USP1 by ML323 presented the similar effects on Hippo signaling pathway and suppressed OS growth and metastasis both in vitro and in vivo."
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"In various types of cancer, USP1 is often overexpressed and mediates the stabilization of inhibitors of DNA binding and cell differentiation (ID proteins family) to regulate tumor proliferation, metastasis and apoptosis [29]."
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"Then, real-time cellular analysis (RTCA) showed that USP1 knockdown inhibited GC metastasis both in vitro and in vivo."
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"Finally, we found that USP1 inhibition inhibited HCC metastasis."
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"Mechanically, we demonstrated that USP1 promoted GC metastasis via upregulating ID2 expression and further confirmed that USP1 stabilized ID2 expression through deubiquitinating ID2 in GC."
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"USP1 can drive growth and metastasis of HCC cells by stabilizing RPS16 (35)."
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"In conclusion, our study showed that USP1 promoted GC metastasis via stabilizing ID2 expression, which provides a potential biomarker and therapy target for GC."
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"USP1 enhances the proliferation, invasion, and metastasis of CCA by stabilizing PARP1."
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"Collectively, these findings indicate that USP1 can promote CCA proliferation and metastasis primarily through PARP1 both in vitro and in vivo."
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"Our results showed that USP1 inhibition by ML323 had the similar impact on Hippo signaling pathway and effectively suppressed the migration, proliferation, EMT, and metastasis of OS both in vitro and in vivo."
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"Suppression of USP1, CDC20, and CASP1 inhibited tumor cell growth and metastasis in ERα KO (ER-/PR +) cell lines."
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"USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis."
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"Correction to: USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis."
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"USP1 Promotes GC Metastasis via Stabilizing ID2."
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"USP1, OUTB1, and USP11 induced migration, invasion, and metastasis through Snail (Figure 2B) [109,111,112]."
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"These findings are consistent with our observation that ML-323 combined with chloroquine can remarkably inhibit HCC growth, suggesting the possibility of targeting USP1 for the treatment of HCC.In addition, USP1 inhibition can significantly inhibit the metastasis of tumor cells."
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