IndraLab

Statements

OTUB1 activates cisplatin. 2 / 2
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reach
"Based on the above results, the fact that OTUB1 promotes cisplatin resistance in BLCA through mediating β-catenin has been confirmed."
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reach
"We also identified the correlation between the OTUB1/β-catenin/necroptosis axis and chemotherapy response in BLCA, demonstrating that elevated OTUB1 promotes cisplatin resistance, which is reversed by XAV-939 application.In conclusion, our study unveils the oncogenic role of OTUB1 in BLCA and integrates the complex relationship among OTUB1, BLCA, β-catenin, and necroptosis."
39113709