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USP22 activates CDK11B. 3 / 3
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"To further validate that USP22 increases hepatocellular carcinoma cell proliferation by stabilising CDK11B protein, we overexpressed His‐CDK11B in USP22 knockout cells (Figure 4F) and evaluated cell proliferation."
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"19 However, there has been a lack of thorough investigation into the role of USP22 in hepatocellular carcinoma development and Sorafenib resistance.In this study, we demonstrate that USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising cyclin‐dependent kinase 11B (CDK11B)."
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"31 To establish the relationship between the promotion of cell proliferation and the stabilisation of CDK11B protein caused by USP22 overexpression, we intended to first examine the effects of CDK11B knockdown on hepatocellular carcinoma cell proliferation."
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