IndraLab

Statements

SCN5A activates Neoplasm Invasiveness. 6 / 6
| 3 3
eidos
"Knockdown of Nav1.5 inhibits cell proliferation , migration and invasion via Wnt / beta-catenin signaling pathway in oral squamous cell carcinoma ."
32400862
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"Taken together, our inhibitor and knockdown experiments suggest that veratridine stimulated invasion by SW620 colon cancer cells is mediated by an SCN5A dependent pathway involving PKA/RAP1B/MEK/ERK (predominant pathway)."
26096612
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"The fact that neither pharmacologic nor genetic knockdown of SCN5A inhibited cell invasion completely may be explained by the presence of other mechanisms that contribute to cell invasion, existence of additional functional isoforms (such as Na v 1.8, encoded by SCN10A, the most TTX resistant isoform; see XREF_SUPPLEMENTARY), or simply incomplete gene knockdown."
20651255
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"In CRC cells, SCN5A knockdown reduced the proliferation, migration and invasion."
33338532
eidos
"Nav1.5 promotes invasion through the CD44-src-cortactin signaling pathway [ 70,104,105,106 ] ."
| PMC
eidos
"In CRC cells , SCN5A knockdown reduced the proliferation , migration and invasion ."
33338532