IndraLab

Statements

USP8 activates FLVCR1. 9 / 9
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"Silencing of USP8 suppresses PCa cell migration and promotes docetaxel activity."
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"Consequently, significantly increased EGFR and PI3K were also found in USP8-overexpressed PCa cell lines compared to the control."
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"The data from Western blotting showed that there was a significantly increased IKKα, phosphorylated IκBα and p65, and p65 found in USP8-overexpressed PCa cells but decreased IκBα compared to control and thereby upregulating the NF-κB activation ( Figures 4C, D )."
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"Overexpression of USP8 promotes PCa cell migration and diminished docetaxel activity."
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"Its overexpression increased the PCa cell migration and diminished the healing action of docetaxel in both cells.Similar to the wound healing assay, overexpression of USP8 resulted in the highest number of migrated cells for both Du145 and PC3 cells in the Transwell assay, which showed statistical significance compared to all other treatment group cells ( Figure 3B )."
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"Therefore, similar to the wound healing assay, it could be stated that USP8 overexpression increased the PCa cell migration and diminished the effect of docetaxel on PCa migration."
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"As USP8 silencing significantly inhibited the PCa cell growth, proliferation, and metastasis and induced apoptosis and suppressed NF-kB signal activation by decreasing EGFR and PI3K, the USP8-specific inhibitor might be a novel therapeutic target to suppress PCa cell growth, proliferation, and metastasis."
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"USP8 silencing significantly inhibits PCa cell growth, survival, and migration and promotes apoptosis by increasing cleaved Caspase 3 and cleaved Caspase 9."
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"This study also shows that USP8 overexpression promotes PCa cell growth, survival, and migration and suppresses apoptosis."
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