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Statements

TNFAIP3 increases the amount of TNF. 4 / 4
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"Therefore, OSA-DEGs, JUN, JUNB, DUSP1, and TNFAIP3 function in OA by increasing TNF-α expression."
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"In the following, reduced activation of TNFAIP3 could increase the IL-6, IL-1β, and TNF-α expression, induce microglial activation, and worsen the neuroinflammation ."
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"RT-qPCR found that silencing TNFAIP3 could downregulate levels of IL-6, TNF-α and IL-1β in cerulein-stimulated AR42J cells, while further overexpression of NLRP3 was conductive to reverse the impact o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although dexamethasone mediated activation of the glucocorticoid receptor (GR) potently repressed expression of IL1beta, IL8, and several other pro inflammatory TNF targets, the expression of anti-inflammatory TNF targets such as TNFAIP3 (A20) and NFKBIA was selectively spared or augmented by dexamethasone treatment."
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