IndraLab

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ERK activates KCNH2. 3 / 3
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"Inhibition of ERK1/2 activity with its specific inhibitor in the irradiated cells suppressed the activation of ERG1 and blocked the induction of RIBE, further confirming the key role of ERK1/2 in RIBE induction."
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"Specifically, we previously showed in striatal cultures7912 that cell surface mGluR5 stimulates CAMKIV, p-CREB and c-jun, while intracellular mGluR5 phosphorylates ERK1/2 and Elk-1, and enhances c-fos, erg-1 and Arc/Arg3.1."
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"Reports have shown that Apelin-13 promotes VSMC proliferation mainly through the PKC–ERK signaling pathway and Erg-1 is activated by ERK protein kinase."
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