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Double-stranded RNA inhibits DDX58. 12 / 12
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"Immunofluorescence analysis using specific dsRNA antibodies showed a significant and time-dependent accumulation of dsRNA in the USP18 KO cells after IFN treatment, indicating that USP18-dependent ISGylation under these conditions could inhibit ADAR activity.In addition to ADAR, PKR, RIG-I and MDA5, we found other proteins involved in antigen presentation and resistance to immunotherapy, such as TAP1, GBP1, STAT1, IFIT1, PSMB10, PSMB9, GBP2, MAGE and PARP14, also regulated by USP18-dependent ISGylation."
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"Tegument protein UL37 of herpes simplex virus 1 (HSV-1) promotes RIG-I deamidation to inhibit viral dsRNA-triggered RIG-I activation (28)."
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"PKR is an intracellular protein that binds dsRNA in a length-dependent fashion and induces apoptosis in the host cell to prevent viral propagation.12 TLR3 , MDA5 , and RIG-I also recognize dsRNA and play an active role in immune activation ."
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"Probably , it is due to the fact that the length of circNDUFB2 is 249 nt , and RIG-I is preferentially activated by short dsRNAs ( < 300 bp ) , whereas MDA5 is preferentially activated by longer dsRNAs ( > 4 kbp ) 52 ."
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"Using a luciferase reporter gene assay, we first 442 evaluated VP35-WT and VP35-S129A inhibition of dsRNA-induced RIG-I activation of the IFN-β 443promoter."
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"This activity enables the NP from Lassa virus to digest free dsRNA, which prevents the activation of RIG-I ."
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"This activity enables the NP from Lassa virus to digest free dsRNA, which prevents the activation of RIG-I 66, 67 ."
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"Second, dsRNA-induced RIG-I activation is impaired in multiple FIP200 deficiency cell lines, including MEF, HEK293, RAW264.7, and BMDM."
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"Both dsRNA and PACT can activate RIG-I while VP35 inhibits RIG-I in a dose-dependent manner in both activation scenarios, which the authors have suggested that VP35 blocks RIG-I both by shielding dsRNA from detection and by preventing PACT binding to RIG-I [7]."
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"This dsRNA contains inosine and inhibits the activation of MDA5 and RIG-1, thus turning off the interferon response and apoptosis to prevent autoimmune reaction."
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"Both dsRNA and PACT can activate Editorial www.impactjournals.com/oncotarget RIG-I while VP35 inhibits RIG-I in a dose-dependent manner in both activation scenarios, which the authors have suggested that VP35 blocks RIG-I both by shielding dsRNA from detection and by preventing PACT binding to RIG-I [7] ."
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"We have previously successfully established knockouts (KOs) of various components of the cell-intrinsic antiviral signaling system in A549 cells, such as RIG-I [19,20,22], MAVS [20], and IRF3 [21], and could demonstrate that such KOs completely abrogate IFN production upon RIG-I stimulation by virus infection or dsRNA transfection."
| PMC