IndraLab

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Double-stranded RNA inhibits RIGI. 19 / 19
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"Using a luciferase reporter gene assay, we first 442 evaluated VP35-WT and VP35-S129A inhibition of dsRNA-induced RIG-I activation of the IFN-β 443promoter."
| DOI
eidos
"Probably , it is due to the fact that the length of circNDUFB2 is 249 nt , and RIG-I is preferentially activated by short dsRNAs ( < 300 bp ) , whereas MDA5 is preferentially activated by longer dsRNAs ( > 4 kbp ) 52 ."
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"For immunology, dsRNA containing multiple groups of I/U inhibits the activity of MDA5, RIG1 and IRF-3, thus inhibiting the induction pathway of IFN-I and affecting the host antiviral response (5, 28) (Figure 4)."
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"While binding to dsRNA relieves autoinhibition for RIG-I, for DRH-I we propose it is the binding of its NTD to DCR-1’s helicase domain, instead of its own helicase domain, that relieves DRH-1’s autoinhibited state (Figure 4)."
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"Both NS1B-CTD and full-length NS1B compete with 5’ppp dsRNA in vitro to suppress RIG-I activation."
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"The inhibitory properties of NS1 appear to be related, at least in part, to its capacity to bind dsRNA ( Cheng et al., 2009 ), which allows it to sequester these molecules and prevent RIG-I activation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"While binding to dsRNA relieves autoinhibition for RIG-I, for DRH-I we propose it is the binding of its NTD to DCR-1’s helicase domain that relieves DRH-1’s autoinhibited state (Figure 4)."
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"Such mechanisms can be categorized into three main actions (22, 23): (i) hide, hiding dsRNA to block RIG-I–like receptor (RLR) accessibility; (ii) mask, altering/editing the dsRNA PAMP signatures to avoid their recognition by RLRs; and (iii) hit, hitting the downstream effectors of the RLR pathway to destroy their functions."
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"N protein bound with Ras GTPase-activating protein-binding protein 1 (G3BP1) to reduce the formation of antiviral stress granule and block the activation of RIG-1 by double-stranded RNA (92)."
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"Immunofluorescence analysis using specific dsRNA antibodies showed a significant and time-dependent accumulation of dsRNA in the USP18 KO cells after IFN treatment, indicating that USP18-dependent ISGylation under these conditions could inhibit ADAR activity.In addition to ADAR, PKR, RIG-I and MDA5, we found other proteins involved in antigen presentation and resistance to immunotherapy, such as TAP1, GBP1, STAT1, IFIT1, PSMB10, PSMB9, GBP2, MAGE and PARP14, also regulated by USP18-dependent ISGylation."
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"Interestingly, stimulation of cells with poly(I:C), a synthetic dsRNA that mimics intracellular dsRNA infection, was reported to promote RIG-I degradation through a proteasome-independent pathway, dem[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have previously successfully established knockouts (KOs) of various components of the cell-intrinsic antiviral signaling system in A549 cells, such as RIG-I [19,20,22], MAVS [20], and IRF3 [21], and could demonstrate that such KOs completely abrogate IFN production upon RIG-I stimulation by virus infection or dsRNA transfection."
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"LGP2 senses dsRNA, and can usually act as an activator of MDA-5 [ 20 ] and inhibitor of RIG-I."
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"Tegument protein UL37 of herpes simplex virus 1 (HSV-1) promotes RIG-I deamidation to inhibit viral dsRNA-triggered RIG-I activation (28)."
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"Second, dsRNA-induced RIG-I activation is impaired in multiple FIP200 deficiency cell lines, including MEF, HEK293, RAW264.7, and BMDM."
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"This activity enables the NP from Lassa virus to digest free dsRNA, which prevents the activation of RIG-I ."
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"ADAR1-edited dsRNA inhibits MDA5 and Rig1 activation (Figure 1a) [41]⁠."
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"PKR is an intracellular protein that binds dsRNA in a length-dependent fashion and induces apoptosis in the host cell to prevent viral propagation.12 TLR3 , MDA5 , and RIG-I also recognize dsRNA and play an active role in immune activation ."
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"These data indicated that quercetin restored the osteogenic differentiation ability of senescent BMSCs, potentially due to the inhibition of the dsRNA-triggered RIG-I receptor signaling pathway."
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