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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mutated SCN5A activates LQT-3. 2 / 2

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"Other less common mechanisms of SCN5A mutations to cause LQT-3 include increased window current [XREF_BIBR, XREF_BIBR], slower inactivation [XREF_BIBR, XREF_BIBR], faster recovery from inactivation [XREF_BIBR, XREF_BIBR], and larger peak I Na density [XREF_BIBR]."

20091048

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"More surprisingly, some SCN5A mutations cause symptoms of both LQT-3 (I Na gain-of-function) and BrS (I Na loss-of-function) in members of one family, or LQT-3 in one family and BrS in another [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

20091048

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...