IndraLab

Statements

ATXN3 activates MDC1. 4 / 7
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"Thus, while RNF4 reduces the chromatin retention of MDC1 in wild-type cells (Galanty etal, 2012), ataxin-3 has the opposite effect and increases the retention time of MDC1 on chromatin."
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"We also show that ataxin-3 promotes efficient MDC1 dependent DSB repair by NHEJ and HR."
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"As a result, Ataxin-3 promotes prolonged retention of MDC1, resulting in reduced recruitment of 53BP1 and BRCA1."
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"Loss of ataxin-3 markedly decreases the chromatin dwell time of MDC1 at DSBs, which can be fully reversed by co-depletion of RNF4."
28275011