IndraLab

Statements

Arachidonic acid inhibits KCNK18. 10 / 11
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"It is unlikely that block of phospholipase A underlies the substantive effects on TREK and TRESK channels seen here, because arachidonic acid enhances TREK (and TRAAK) channels (Fink et al., 1996; Enyedi and Czirják, 2010) and blocks TRESK channels (Sano et al., 2003; Kang et al., 2004)."
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"In contrast, TRESK is inhibited by AA and docosahexaenoic acid [XREF_BIBR]."
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"Arachidonic acid (AA), lidocaine, and lamotrigine inhibited the activity of TRESK-like channel by 25 ± 6%, 77 ± 8%, and 46± 10%, respectively, in the cell-attached patches (Figure 3E, n = 5)."
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"Arachidonic acid (AA), lidocaine, and lamotrigine inhibited the activity of TRESK-like channel by 25 ± 6%, 77 ± 8%, and 46± 10%, respectively, in the cell-attached patches (Figure 3E, n = 5)."
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"TRESK like currents in trigeminal neurons were additively inhibited by arachidonic acid, acidic pH and hypertonic stimulation, conditions usually found after tissue inflammation."
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"As expected, AA (10 microM) produced a 42.6 +/-4.2% decrease in TRESK current recorded at +20 mV (n = 14; p < 0.001; XREF_FIG)."
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"TRESK channel is inhibited by arachidonic acid [59] but directly activated by calcineurin after G q receptor stimulation and a subsequent rise in intracellular calcium [89]."
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"In contrast, TRESK is inhibited by arachidonic acid, but the channel can still be modulated by mechanical stimuli."
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"Similar to cloned TRESK, native TRESK was inhibited by acid and arachidonic acid (AA), but not zinc."
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"In contrast, TRESK is inhibited by arachidonic acid, but the channel can still be modulated by mechanical stimuli."
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