IndraLab

Statements

CYLD decreases the amount of BCL3. 2 / 5
| 2
reach
"CYLD deubiquitylates BCL-3 inhibiting its nuclear translocation and so decreases the transcription of BCL-3 target genes including CCND [XREF_BIBR]."
28900014
reach
"In agreement with the mechanism in keratinocytes, CYLD markedly reduced expression of Cyclin D1 (XREF_FIG), cyclin D1 promoter activity (XREF_FIG), and BCL-3 recruitment to the cyclin D1 promoter in a complex with p50 or p52 (XREF_FIG, left) as compared with cells transduced with viral vectors carrying a catalytically inactive mutant of CYLD (C/S-CYLD), a GFP expression cassette or noninfected cells."
19124656