IndraLab

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Luteolin inhibits JUN. 5 / 7
2 | 5

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"Luteolin was able to inhibit the activation of c-Jun N-terminal kinases (p-JNK), p38 mitogen-activated protein kinases, glial fibrillary acidic protein (GFAP), and ionized calcium adaptor molecule 1 (IBA1) in the cortex and hippocampus of mice."

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"Moreover, IL-1beta-induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation were inhibited by luteolin."

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"Moreover, luteolin attenuated IS-induced nuclear accumulation of p65 and c-jun."

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"In addition, miR5119, miR5108, and luteolin in H-VLNs were identified to synergistically inhibit C-JUN and NF-κB pathways."

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"Furthermore, the study found that luteolin treatment prevented the activation of activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) induced by IL-1β."