IndraLab

Statements

USP6 binds PPP6R3. 5 / 5
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"Both cases harbored a PP6R3::USP6 fusion and intriguingly amplification of the fused allele xref – xref ."
37150655
sparser
"In the literature there are two cases reported with a PPP6R3::USP6 fusion and typical morphology of a nodular fasciitis but with a malignant transformation [ xref , xref ] ."
37951844
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"In the literature, we encountered two cases with malignant clinical course. xref , xref In contrast to our case, both showed classical histologic features of NF and a PPP6R3–USP6 fusion with additional amplification suggesting that this specific amplified fusion gene is causative for the aggressive clinical course of the disease."
33625261
sparser
"For example, a PPP6R3-USP6 fusion gene with amplification has been observed in rare cases of malignant NF, suggesting that this genetic alteration may confer malignant potential."
39445266
sparser
"This case illustrates a rare and challenging presentation of histologically benign but clinically malignant nodular fasciitis, associated with a PPP6R3-USP6 fusion and ERBB2 mutation."
41646441