IndraLab

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USP22 activates cell growth. 18 / 21
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"Second, USP22 significantly increased cell growth in the presence of androgen (XREF_FIG, right)."
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"Finally, we discover that USP22 knockdown leads to slower cell growth and reduced tumor size."
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"USP22 Promotes Ligand dependent and Castrate resistant PCa Cell Growth."
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"Taken together, our results suggest that USP22 promotes NSCLC cell growth in vitro and NSCLC tumorigenesis in vivo, and these effects are through MDMX up-regulation and subsequent p53 inhibition."
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"Our group first demonstrated that knockdown of USP22 induces cell cycle arrest and inhibits cell growth in the HCC cell line HepG2 [ 8] ."
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"Third, and most critically, USP22 robustly promoted cell growth and proliferation in the absence of androgen."
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"Gain- and loss-of-function assays showed that USP22 promoted gastric cancer cell growth and cell cycle transition while suppressing apoptosis in vitro."
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"Our group first ensured that knockdown of USP22 can induce cell cycle arrest and inhibit cell growth in the HCC cell line HepG2 (Ling etal., 2012a)."
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"In addition, we present evidence that USP22 promotes Bel/Fu cell growth, migration, invasion, EMT and chemoresistance."
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"Our results demonstrated that USP22 silencing suppressed cell growth and induced cell apoptosis."
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"Moreover, it has been shown that USP22 promotes cell growth by regulating the far upstream element (FUSE)-binding protein 1 (FBP1), a transcriptional regulator of p21 [XREF_BIBR]."
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"USP22 promotes cell growth even under hypoxia condition and with the treatment of ERalpha antagonist in breast cancer cells."
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"Collectively, our results show that USP22 silencing in HepG2 cells suppressed cell growth through mitochondrial apoptosis and that this suppression was dependent on caspase activation."
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"Our data showed that USP22 silencing led to significantly slower cell growth compared with the control (p < 0.01 after 120 h) (XREF_FIG B)."
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"Knockdown of USP22 significantly retarded cell growth in H1975 cells compared to control (p < 0.05, Fig. 2 A), whereas overexpression of USP22 in PC9 cells accelerated cell growth (p < 0.01, Fig. 2 A)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indeed, compared with control, we found that the USP22 knockdown cells grew significantly more slowly in H1650 (p < 0.05, Fig. 2 B) and the USP22 overexpression in A549 accelerated cell growth (p < 0.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 regulates CCNB1 protein stability to promote cell cycle progression, as well as cancer cell growth, when it is aberrantly upregulated."
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"These observations indicate that USP22 gene silencing by RNA interference inhibits HCC cell growth."
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