IndraLab

Statements

KCNH2 inhibits GCG. 4 / 4
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"Pharmacological Kv11.1 blockade (dofetilide) in rats had similar effects and inhibition of hERG in beta and L cells directly increased insulin and GLP-1 secretion by up to 50%."
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"Moreover, small interfering RNA mediated knockdown of Kcnh2 in the GLUTag enteroendocrine cell line increased the magnitude of glucose stimulated GLP-1 release, implicating a direct role for hERG in c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We also show that inhibition of hERG directly increases secretion of both insulin and GLP-1 from cultured beta and L cells, respectively."
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"Pharmacological Kv11.1 blockade (dofetilide) in rats had similar effects and inhibition of hERG in beta and L cells directly increased insulin and GLP-1 secretion up to 50%."
28235848