IndraLab
Statements
"As shown, both AKT and ATM increase the activity of USP10.|Yuan et al. demonstrated that ATM could phosphorylate USP10 at Thr42 and Ser337 upon the DNA-damage response and USP10 was translocated into the nucleus, where the N-terminus of USP10 (amino acids 1–100) binds to p53 and inhibits its ubiquitination [27]."
reach
"However, upon exposure to external stress such as high concentrations of hydrogen peroxide [65], the inhibition of USP10 by G3BP1 is abrogated and USP10 is induced to phosphorylate by ataxia-telangiectasia-mutated protein (ATM) or activated by ATM-phosphorylated protein, thereby reducing ROS production and apoptosis [64]."
"As shown, both AKT and ATM increase the activity of USP10.|Yuan et al. demonstrated that ATM could phosphorylate USP10 at Thr42 and Ser337 upon the DNA-damage response and USP10 was translocated into the nucleus, where the N-terminus of USP10 (amino acids 1–100) binds to p53 and inhibits its ubiquitination [27]."