IndraLab

Statements

Tranilast inhibits NLRP3. 14 / 14
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"Tranilast also acts to inhibit NLRP3 inflammasome specifically without disrupting the activation of the other known inflammasomes such as NLRC2 and AIM2."
34015982
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"Tranilast is a direct inhibitor of NLRP3 by binding to the NACHT domain and it suppresses the inflammasome assembly by blocking the oligomerization of NLRP3 (Huang et al., 2018)."
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"A single-arm prospective cohort (phase II) study designed to observe the efficacy and safety of tranilast (a small molecule inhibitor of the NLRP3 inflammasome) in CAPS patients."
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"Moreover, tranilast inhibited the activation of the NLRP3 inflammasome in vivo, demonstrating a protective effect on NLRP3 mediated acute inflammation and tissue damage, which could be employed in clinical practice ."
34053242
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"Like the three specific inhibitors mentioned above, Tranilast does not interfere with the upstream signaling pathways of NLRP3 inflammasome, including NLRP3 and pro-IL-1beta expression, K + efflux, mitochondrial damage, ROS production, and chloride efflux, and can not prevent the newly identified NLRP3 inflammasome component NEK7 from interacting with NLRP3 109."
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"Moreover, tranilast inhibited the activation of the NLRP3 inflammasome in vivo, demonstrating a protective effect on NLRP3 mediated acute inflammation and tissue damage, which could be employed in clinical practice (Huang et al., 2018)."
34053242
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"The results of these studies are presented in the form of review articles in which the efficacy of NLRP3 inflammasome inhibitors like Tranilast, has been suggested (Table 1)."
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"Unlike the CY-09 identified by the same group, Tranilast inhibits NLRP3 inflammasome activation via an ATPase independent manner, by blocking direct NLRP3-NLRP3 interaction 109."
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"Tranilast markedly suppressed NLRP3 inflammasome activation in low-density lipoprotein receptor- and apolipoprotein E deficient macrophages."
32476536
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"Tranilast is an antagonist of NLRP3 that inhibits the inflammasome pathway."
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"Additionally, tranilast remarkably reduced the elevated expression of NLRP3 and proinflammatory cytokines."
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"NLRP3 Inhibitor Tranilast Attenuates Gestational Diabetes Mellitus in a Genetic Mouse Model."
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"Moreover, triple combination drug treatment comprising of amlexanox (TBK1/IKKα inhibitor), SS-31 (mitochondria-targeted antioxidant) and tranilast (an inhibitor of NLRP3) reduces redox stress-mediated mitophagic flux, lysosome enlargement and cell death [34]."
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"As a safe small-compound drug employed frequently in clinic, tranilast (TR) is newly reported to block the activation of NLRP3 inflammasome in macrophage."
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