IndraLab

Statements

SOCS1 inhibits USP7. 2 / 2
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"Given the positive results from SOCS1 and SOCS3 inhibitors in reducing viral loads, such as pJAK2 1001–1013, miRNA‐19a, ubiquitin‐specific protease 7 (USP7) and zoledronic acid (ZA), it is important to consider the potential of SOCS inhibitors in the context of SARS‐CoV‐2 infection."
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"Mechanically, we demonstrated that DDX4 negatively regulates the expression and stability of SOCS1 protein in a USP7-dependent manner by inhibiting the interaction of USP7 with SOCS1, thus strengthening the antiviral function of IFN-I."
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