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"Conversely, the activation of HH signaling induced by the agonist purmorphamine results in an up-regulation of USP37 gene expression, subsequently leading to the stabilization of GLI1 and influencing EMT in breast CSCs.295 Furthermore, Zhou et al discovered that USP48, a deubiquitinase enzyme, activates the Hh signaling pathway by enhancing the stability of the Gli1 protein in glioma cells.296 Through its C-terminal DUSP structural domain, USP48 interacts with Gli1 and removes Ub molecules from it."