IndraLab

Statements

HEY1 inhibits USP11. 8 / 8
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"Overexpression of Hey1 in GBM cell lines U87 decreased USP11 mRNA and protein (XREF_FIG)."
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"Hey1 represses USP11 to downregulate PML."
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"Thus, Hey1 functions as a transcriptional corepressor in USP11 transcription regulation and a complex crosstalk among transcriptional factors, histone modifiers and DNA methylation is involved in Hey1 mediated repression of USP11."
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"In the reciprocal experiments, Hey1 knockdown in U87 and U251 cells upregulated USP11 mRNA, USP11 protein and PML protein, but not PML mRNA (XREF_FIG)."
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"We have elucidated the mechanism by which Hey1 represses USP11 promoter activity (XREF_FIG)."
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"Importantly, Hey1 induced repression of USP11 was abrogated partially by mutating either of the first two Sp1 sites and completely by disrupting both (XREF_FIG), suggesting that Hey1 acts through Sp1 binding sites to repress USP11."
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"Using luciferase reporter assay, we found that Hey1 repressed the USP11 promoter activity and that the +171/+335 (0.16 K) region of USP11 promoter was responsible for this repression (XREF_FIG)."
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"We further showed that USP11 is transcriptionally repressed by the Notch effector Hey1."
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