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USP47 activates TP53. 2 / 2

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"In this study, we investigate the functional and biochemical properties of USP47, whereby depleting USP47 inhibited cancer cell growth in a p53-dependent manner--a phenomenon that enhances during the simultaneous knockdown of USP7."

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"Interestingly , p53 decrease by USP47 overexpression and p53 increase by USP47 knockdown were only shown in the MDM2 + / + p53 - / - MEF cell line , while there were no significant p53 level changes in the MDM2 - / - p53 - / - MEF cell line ( Figure 2e , f ) ."

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USP47 activates TP53. 2 / 2

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