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PRPF8 inhibits helicase. 1 / 1

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"Thus, how BRCA2 inactivation may increase intracellular ROS levels remains an open question.A further clue to the link between BRCA2 deficiency and ROS accumulation comes from our observation that depletion of the R-loop helicase, SETX, or the spliceosome factor, PRPF8, also suffices to induce endogenous oxidative stress and mitochondrial defects (Figure 7)."

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PRPF8 inhibits helicase. 1 / 1

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