IndraLab

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BRCC3 activates ZEB1. 5 / 5
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"The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells."
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"We also found that interfering with BRCC3-mediated ZEB1 degradation was completely inhibited by the proteasome inhibitor MG132 ( Figure 3E)."
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"In conclusion, BRCC3 promotes TNBC cell proliferation and metastasis by increasing the stability of ZEB1 under pathological conditions."
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"Based on our findings, we hypothesized that BRCC3 may increase ZEB1 stability and upregulate ZEB1 expression through deubiquitination, thereby promoting TNBC cell proliferation, migration, invasion, EMT and metastasis."
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"The aim of this study was to investigate the role of BRCC3-mediated increase of ZEB1 stability in influencing the progression of TNBC."
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