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OTUB2 activates cell population proliferation. 23 / 23
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"Knockdown of OTUB2 inhibits breast cancer cell proliferation and migration."
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"OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer."
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"OTUB2 depletion by two independent shRNAs promoted the proliferation of OVCA429 cells (Fig. 2G and SI Appendix, Fig. S2 F and H)."
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"The overexpression of OTUB2 promoted glycolysis and induced the proliferation, migration, and invasion of endometrial cancer cells."
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"Correction: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer."
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"We also confirmed that OTUB2 enhanced the proliferation, migration, and invasion abilities of NSCLC cells In vitro."
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"Correction: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer."
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"The plate clone formation assay showed that compared with the control group, the clone formation ability of KYSE150 and shNC was significantly decreased and the number of cells was decreased (P < 0.05), which suggested that the proliferation of ESCC could be inhibited by OTUB2 knockdown (Fig. 8B, C)."
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"These authors found that OTUB2 could directly act on YAP1/TAZ independently of the Hippo signaling pathway to promote tumor proliferation."
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"OTUB2 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by PJA1 Deubiquitylation."
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"The CCK8 data, colony formation assays and wound healing data indicated that OTUB2 significantly enhanced tumor cell proliferation in vitro ( Fig. 2 A–C)."
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"38 In the most recent studies, Ouyang et al investigated the mechanisms by which OTUB2 regulates KRT80 stability and thereby promotes proliferation in GC."
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"In vitro experiments verified that knockdown of OTUB2 could inhibit the proliferation and migration of breast cancer.Conclusions: The DUBRI discovered in this research may effectively evaluate the outlook of breast cancer patients and identify groups of patients who would gain advantages from immunotherapy, offering vital knowledge for the future targeted treatment of breast cancer patients."
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"Functionally, the overexpression of OTUB2 could promote malignant proliferation and metastasis of HCC cells, while knockdown of OTUB2 exerted the opposite results."
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"In conclusion, our study indicated that OTUB2 could promote the malignant proliferation and migration of HCC cells by increasing the stability of PJA1 via deubiquitylation."
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"Given that OTUB2 promotes gastric cancer growth and proliferation by positively regulating the activation of the PI3K/AKT signaling pathway via KRT80, we believe that KRT80 also has clinical effects similar to OTUB2."
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"Overexpression of OTUB2 enhanced the proliferation and migration of TNBC cells, while its knockdown inhibited these processes."
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"We conducted CCK8 assay (Fig. S1A), colony formation assay (Fig. S1B), and flow cell cycle assay (Fig. S1C), collectively revealing that manipulation of OTUB2 expression either suppressed or enhanced cell proliferation."
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"Inhibition of OTUB2 promotes apoptosis and attenuates proliferation and metastasis of CC cells by downregulating the AKT/mTOR signalling pathway (Ref."
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"Nevertheless, the pathophysiological function of OTUB2 in triple-negative breast cancer remains indistinct.Here, we identified the upregulation of the deubiquitinase OTUB2 in TNBC through differential analysis, both in vivo and in vitro experiments showed that OTUB2 significantly promotes TNBC cell proliferation and migration."
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"OTUB2 promotes TNBC cell proliferation in vitro and tumor growth."
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"The present work demonstrated that OTUB2 knockdown significantly inhibited the proliferation of iCCA cells while promoting apoptosis, suggesting that increased cell proliferation and decreased apoptos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, overexpression of OTUB2 promoted TNBC cell proliferation and migration, whereas silencing of OTUB2 resulted in the opposite effect."
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