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"Furthermore, gstD1-GFP and p53 upregulation was also observed in imaginal disc cells overexpressing the pathogenic RP13-linked mutant variant of Prp8 protein (Drosophila Prp8 /human PRPF8 ) (Supplementary Figure 1H–M), suggesting a shared response to U5 snRNP malfunction, inflicted either by scarcity of the biogenesis factor or mutation in the core splicing factor."