IndraLab

Statements

USP14 inhibits NLRC5. 5 / 6
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"Next, we tested whether USP14 also enhanced NLRC5 mediated inhibition of TRAF2/6 independent noncanonical NF-kappaB signaling."
26620909
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"USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis."
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"These results suggest that USP14 specifically enhanced NLRC5 mediated inhibition of NF-kappaB activation through the inhibition of NLRC5 ubiquitination via its DUB activity."
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"Because USP14 specifically enhanced NLRC5 mediated inhibition of NF-kappaB activation, we reasoned that USP14 deficiency would result in the accumulation of ubiquitinated NLRC5 and increased NF-kappaB activation under physiological conditions."
26620909
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"These results suggest that USP14 inhibits NF-kappaB signaling in an NLRC5 dependent manner."
26620909