IndraLab

Statements

USP5 activates TP53. 6 / 8
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"Knockdown of the mammalian IsoT (USP5) causes a similar accumulation of polyubiquitin as well as an increase in the proteasomal substrate p53 [XREF_BIBR]."
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"It has recently been shown that knock-down of the deubiquitinating enzyme USP5 (isopeptidaseT) causes p53 activation XREF_BIBR."
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"Depletion of USP5 has been reported to cause accumulation of nuclear p53 and increase p53 transcriptional activity."
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"Intriguingly, USP5 has been confirmed to mediate p53 signaling XREF_BIBR, wnt-beta-catenin pathway XREF_BIBR, Type I interferon signaling pathway XREF_BIBR, Notch and RTK signaling pathway XREF_BIBR."
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"In previous study, p53 stabilization was mediated by Usp5 through accumulation of unanchored poly-ubiquitin chains which competed with p53 for entering into the proteasome [XREF_BIBR]."
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"Usp5 KD resulted in up-regulation of p53 in w/t p53 A375 cells and up-regulation of p73 in p53 mutant SK-Mel28 cells, suggesting that both proteins can be modulated by Usp5."
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