IndraLab

Statements

Bortezomib inhibits TRAF6. 11 / 11
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"It has been reported that bortezomib can induce proteasome independent degradation of TRAF6 in myelodysplastic syndrome [XREF_BIBR]."
29703234
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"Bortezomib inhibits activation of TRAF6 and NF-kappaB activity."
29703234
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"To determine whether degradation of TRAF6 by bortezomib occurs via UPS, a proteasome inhibitor (MG132) was evaluated."
29703234
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"More recently, it was demonstrated that bortezomib (a proteasome inhibitor) induces proteasome-independent degradation of the TRAF6 protein in myelodysplastic syndrome; such as acute myeloid leukemia [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26052093
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"Cytotoxic effects of bortezomib in myelodysplastic syndrome and acute myeloid leukemia depend on autophagy mediated lysosomal degradation of TRAF6 and repression of PSMA1."
22685174
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"Cytotoxic effects of bortezomib in myelodysplastic syndrome and acute myeloid leukemia depend on autophagy mediated lysosomal degradation of TRAF6 and repression of PSMA1."
24552120
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"Most importance of all, besides the anti-myeloma properties, we found that low concentrations of bortezomib were able to inhibit the upstream signal TRAF6 protein in osteoclasts, presenting as diminis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18778854
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"Augmented TLR signaling inhibition can also be achieved by combining emavusertib with a proteasome inhibitor such as bortezomib which via lysosomal degradation, can degrade the TLR-signaling intermediate TRAF6, leading to apoptosis of AML/MDS cells (92)."
37954584
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"These results illustrate that bortezomib can inhibit the activation of TRAF6 and NF-kappaB activity in SAS cells."
29703234
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"Paradoxically, we find that bortezomib induces proteasome independent degradation of the TRAF6 protein, but not mRNA, in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) cell lines and primary cells."
22685174
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"Hongming H, Jian H. Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6."
29495905