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"Moreover, overexpression of TREK-1 significantly decreased the phosphorylation of Akt (S473), glycogen synthase kinase-3beta (S9) and cAMP response element binding protein (CREB, S133), enhanced the phosphorylation of p38 (T180 and Y182), but did not alter the phosphorylation and expression of signal transducer and activator of transcription 3 (STAT3)."