IndraLab

Statements

Pseudouridine inhibits IFIH1. 3 / 3
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"Furthermore, abundant cellular RNAs such as tRNAs and rRNAs are extensively modified with unusual bases such as pseudouridine that prevent activation of RIG-I and MDA-5 [26] ."
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"N6-methyladenosine (m6A), 5-methylcytidine (m5C), 2ʹ-O-methylation (2ʹ-O-Me), and pseudouridine (ψ) are demonstrated to inhibit melanoma differentiation-associated protein 5 (MDA5) or retinoic acid-inducible gene I (RIG-I) mediated sensing."
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"In addition, abundant cellular RNAs, such as tRNAs and rRNAs, are extensively modified with unusual bases, such as pseudouridine, which prevent the activation of RIG-I and MDA5 (Ref."
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