IndraLab

Statements

PPARGC1A binds BAP1. 4 / 4
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"Conversely, O -GlcNAcylation of the transcriptional regulator PGC1α facilitates the binding of the deubiquitinase BAP1 to PGC1α, leading thus to its stabilization by blocking its ubiquitination ( xref )."
30853938
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"PUGNAc treatment promotes the interaction between PGC-1alpha and BAP1, while it has no effect on the S333A mutant (XREF_FIG), suggesting that O GlcNAcylation of PGC-1alpha facilitates BAP1 binding."
22883232
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"38 Furthermore, the authors found that high-glucose conditions potentiated PGC1alpha glycosylation, suggesting that this O-GlcNAc-induced PGC1alpha and BAP1 complex may provide a functional explanation for the aberrant induction of hepatic gluconeogenesis in hyperglycemic patients."
29099585
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"PGC-1α can also be regulated by BAP1, which directly binds to O-GlcNAcylated PGC-1α to prevent its degradation ( xref )."
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