IndraLab

Statements

USP19 inhibits TBK1. 3 / 3
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"Here, we demonstrate that USP19 (ubiquitin specific peptidase 19) interacts with and promotes TBK1 lysosomal degradation via chaperone-mediated autophagy (CMA)."
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"Furthermore, USP19 deficiency in macrophages caused an elevation of TBK1 and the activation of the type-I interferon signaling pathway after vesicular stomatitis virus (VSV) infection."
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"51 It has been reported further that USP19 promotes TBK1 degradation through chaperone-mediated autophagy.52 Severe acute respiratory syndrome coronavirus 2 M protein also interacts with TBK1 and induces TBK1 degradation by K48-linked ubiquitination."
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