IndraLab

Statements

Withaferin A inhibits NLRP3. 7 / 7
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"Finally, we determined whether WA can directly inhibit ac tivation of the NLRP3 inflammasome."
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"In addition , withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms ."
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"NLRP3 inflammasome activation is a well documented pathway for inflammation induction in macrophage in vitro and in various diseases models in rodents XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, while WA directly antagonizes NLRP3 inflammasome activation in vitro XREF_BIBR, XREF_BIBR."
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"Notably, WA significantly reduced the activation of the NLRP3 inflammasome."
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"Furthermore, WA inhibited the NLRP3 inflammasome induced by ATP, nigericin, and MSU, which are well known NLRP3 activators."
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"The inhibitory effects of WA in LPS induced upregulation of Tnfa, Il6, Il1b, were lost in Nlrp3 -/- macrophage when WA was used at the lower dose of 0.2 microM, while this effect was still found with WA at the higher dose of 0.5 microM in Nlrp3 -/- macrophage, suggesting that WA has both NLRP3 dependent and NLRP3 independent anti-inflammatory effects."
33574236
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"In addition, withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms."
| PMC