IndraLab

Statements

Withaferin A inhibits NLRP3. 11 / 11
| 1 9 1
sparser
"Withaferin A inhibited hepatic NLRP3 and upregulated the expression of NRF2."
38794167
eidos
"In addition , withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms ."
| PMC
reach
"Notably, WA significantly reduced the activation of the NLRP3 inflammasome."
30468675
reach
"The inhibitory effects of WA in LPS induced upregulation of Tnfa, Il6, Il1b, were lost in Nlrp3 -/- macrophage when WA was used at the lower dose of 0.2 microM, while this effect was still found with WA at the higher dose of 0.5 microM in Nlrp3 -/- macrophage, suggesting that WA has both NLRP3 dependent and NLRP3 independent anti-inflammatory effects."
33574236
reach
"Withaferin A inhibits the progression of pancreatitis by blocking Endoplasmic Reticulum (ER) stress and the NLRP3 inflammasome (Kanak et al., 2017)."
36578541
reach
"Withaferin A (WA), a withanolide extracted from Withania somnifera inhibits NF-κB induced NLRP3 in murine bone marrow derived dendritic cells infected with H. pylori [ 78 ]."
30316008
reach
"Withaferin A (WA), a withanolide extracted from Withania somnifera inhibits NF-κB induced NLRP3 in murine bone marrow derived dendritic cells infected with H. pylori [ 78 ]."
30316008
reach
"Furthermore, WA inhibited the NLRP3 inflammasome induced by ATP, nigericin, and MSU, which are well known NLRP3 activators."
26770181
reach
"In addition, withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms."
| PMC
reach
"NLRP3 inflammasome activation is a well documented pathway for inflammation induction in macrophage in vitro and in various diseases models in rodents XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, while WA directly antagonizes NLRP3 inflammasome activation in vitro XREF_BIBR, XREF_BIBR."
33574236
reach
"Finally, we determined whether WA can directly inhibit ac tivation of the NLRP3 inflammasome."
26770181