IndraLab

Statements

USP1 bound to WDR48 activates USP1. 4 / 4
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"USP1 binds to USP1-associated factor 1 (UAF1), which stimulates the deubiquitinase activity of USP1 [45]."
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"Studies show that the formation of the USP1/UAF1 complex greatly enhances the catalytic activity of USP1, but USP1 alone has a very low level of activity (Cohn et al., 2007; Villamil et al., 2012)."
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"Several studies showed that UAF1 forms a complex with USP1 and stimulates the deubiquitination activity of USP1 both in vitro and in vivo."
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"Notably, ID1 is a substrate of USP1 [51], and blockade of USP1 by ML323 (a selective inhibitor of the USP1-UAF1 complex) not only promoted CD8 T-cell infiltration and function but also markedly inhibited the liver metastasis of CRC in an orthotopic liver metastatic syngeneic mouse model [19] (Table 1)."
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