IndraLab

Statements

PRKN activates ATXN3. 4 / 4
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reach
"Although in this case, the E3 ligases that are acting redundantly to CHIP have not been identified, overexpression of either CHIP or parkin promotes the degradation of nNOS and polyglutamine expanded ataxin-3."
20404045
reach
"Parkin also promotes ubiquitination and degradation of a polyglutamine expanded ataxin-3 and reduces its cellular toxicity [XREF_BIBR, XREF_BIBR]."
20674814
reach
"Parkin selectively associates with and promotes the ubiquitylation and degradation of polyQ expanded GFP-polyQ fusion protein or ataxin-3 in vivo and in vitro."
17127076
reach
"Our results raise the possibility that parkin mediated K63 linked polyubiquitination may function upstream of ataxin-3 during aggresome formation."
26563499