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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Temsirolimus activates ATXN3. 1 / 1

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"However, consistent with mTOR inhibition inducing autophagy, ataxin-3 transgenic mice treated with temsirolimus showed decreased levels of phosphorylated S6 ribosomal protein (a downstream target of the mTOR pathway), and levels the mutant protein in the cytosol were decreased, as were the number of aggregates."

20007218

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...