IndraLab

Statements

Ubiquitin inhibits BAP1. 3 / 3
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"CoIP of Flag-HIF-1α showed reduced ubiquitin levels when cells overexpressed BAP1, but not in cells overexpressing the catalytic inactive BAP1(C91S), compared to mock control (Fig. 5A)."
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"The fact that an ubiquitin conjugate can inhibit BAP1 to a greater extent than ubiquitin alone, illustrates how this DUB prefers binding its target (ubiquitin conjugate) over its product (ubiquitin alone)."
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"ASXL1 WT could induce H2AK119 ubiquitination (Ub) through negatively regulating BAP1 which removes ubiquitination of H2AK119 as a deubiquitinase (Fig. 2b)."
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