IndraLab

Statements

Mutated TP53 activates mutated TP53. 7 / 7
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"Many cancers have TP53 mutations , many of which produce mutant p53 gain-of-function proteins, leading to tumorigenesis, tumor development, and metastasis ."
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"In H3.3-G34R/V mutant gliomas, TP53 mutations lead to nonfunctional mutant p53 that exhibits nuclear accumulation."
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"Also, the TP53 mutation produces a mutant P53 gene which acts as an oncogene, thereby increasing the aggressiveness, survival and metastasis ability of the tumour cell [13], [14]."
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"Mutant p53 expression in H1299 cells significantly promoted lung metastatic tumor formation, demonstrating mutant p53 GOF in promoting tumor metastasis (Fig. 7I,J)."
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"The non-cell-autonomous effects of TP53 mutations therefore massively support the numerous cell-intrinsic, pro-metastatic functions of mutant p53 and make TP53 mutations even more powerful drivers of tumor growth and metastasis."
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"Indeed, enforced expression of mutant p53 in p53-deficient mouse or human cell lines has been reported to lead to new phenotypes [91], supporting the GOF effects of mutant p53."
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"In the absence of stress, p53 is stochastically expressed, activating nuclear Akt in an on/off mode, whereas mutant p53 is highly expressed and activates nuclear Akt constitutively, reflecting the hyperstability of mutant p53 relative to p53 ."
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