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Dioxygen activates KCNH2. 3 / 3
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"Both L-arginine (10 mM) and NOC-18 (0.3 mM) counteracted the stimulatory effect on hERG1 outward currents induced by the radical oxygen species generating system FeSO (4) (25 microM)/ascorbic acid (50 microM; Fe/Asc)."
10570058
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"Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein."
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"Besides, it has been demonstrated that hERG is negatively modulated by hyperglycemia, tumor necrosis factor, ceramide and reactive oxygen species which are cellular metabolites accumulated in diabetic tissues [XREF_BIBR, XREF_BIBR]."
33520105