IndraLab

Statements


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"Nuclear BAP1 is also associated in chromatin remodeling (49), DNA double-strand repair (50,51), and auto-deubiquitylation promoting its own nuclear localization (52)."

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"BAP1 inactivation promotes lactate production by leveraging the subcellular localization of LDHA in melanoma."

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"It was recently shown that the ubiquitin conjugating enzyme UBE2O multi-monoubiquitinates tumor suppressor BAP1 on its NLS bp to promote cytoplasmic localization."

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"For example, UBE2O binds to and multi-monoubiquitinates BAP1 to induce its cytoplasmic localization and promotes adipocyte differentiation [XREF_BIBR]."