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USP8 inhibits autophagy of mitochondrion. 5 / 5
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"USP8 Inhibition Induces Mitophagy in Neurons of Human Origin."
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"In these neurons of human origin, we found that USP8 pharmacological inhibition by DUBs-IN-2 (0.5–1 μM/24–48 h) enhances basal mitophagy, an effect that was comparable to 0.5 μM antimycin/oligomycin (AO) treatment, which we used as positive control for mitophagy induction (Figure 4C)."
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"Clec16-RNF41-USP8 complex led to regulated mitophagy and normal insulin secretion, while disruption of the complex by stressors induced aberrant mitophagy and impaired β-cell function [60], [61]."
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"These approaches allowed identifying a mitophagic effect of USP8 down-regulation, which was clearly detectable in vivo in the fly brain and also in neurons of human origin.Interestingly, USP8 down-regulation promoted basal mitophagy in a Parkin-independent fashion (Figure 2D,E), whereas it inhibited Parkin mitochondrial translocation and mitophagy under stress condition (Supplementary Figure S3)."
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"TLR4 has central role in HCC genesis by promoting the malignant transformation of epithelial cells and these data show that USP8 negatively regulates NF‐κB activation and mitophagy induction."
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